Call your doctor for medical advice about side effects. Hirschfeld RM. Resnick SD. Each bottle should contain a drying agent (desiccant) that helps keep moisture in the air from damaging the drug. Adverse interactions between warfarin and nonsteroidal antiinflammatory drugs: mechanisms, clinical significance, and avoidance. Keep the bottle tightly closed. Although potentiation of warfarin by lovastatin has been reported in at least 10 patients, controlled trials in large numbers of patients are needed to discern the clinical importance of this effect.Over the past 15 years, selective serotonin reuptake inhibitors (SSRIs) have become the most commonly used antidepressant drugs. Krishnarao I.

et al. Monitor phenobarbital levels.Clinical significance has not been established. Ament PW, Sildenafil therapy should be initiated in the lowest dosage (25 mg) in patients who are also taking a cytochrome P450 3A4 inhibitor.The benefits of lowering cholesterol levels for the primary and secondary prevention of coronary artery disease have been well established. Blackburn KH.

Creatine kinase levels should be measured if these symptoms occur.Lovastatin may potentiate the effects of warfarin by displacing the drug from plasma protein binding sites or inhibiting hepatic metabolism of the drug. A recent retrospective study of 356 patients who were taking an oral contraceptive and an antibiotic showed a small but insignificant increase in the risk of pregnancy.The failure of oral contraception may be suggested by breakthrough bleeding. Mason BJ, These agents are eliminated through hepatic metabolism. Drug interactions are common whenever one medication is prescribed alongside another. Blier P, Oral contraceptive failure rates and oral antibiotics. Laupacis A, Drug interactions overview.

Some clinically important drug interactions. Ray WA,

Consider whether metoclopromide therapy is appropriate for the patient.Avoid if possible. Antibiotics Interaction with Triumeq Triumeq is not to be used by individuals with moderate or severe hepatic impairment. Sedatives/hypnotics: midazolam, alprazolam, triazolam; Co-administration should be avoided if possible.

Alternative antimicrobial therapy is recommended for these patients.Some investigators advise that the hypothrombinemic response to warfarin can increase when acetaminophen is taken in a dosage of more than 2 g per day for longer than one week.One case-control study identified acetaminophen as a cause of 30 percent of INR values greater than 6.0 in patients taking warfarin.Because acetaminophen is the most frequently ingested medication in the United States, physicians should counsel warfarin-treated patients about the potential risks of a warfarin-acetaminophen interaction. Adverse consequences of fluoxetine-MAOI combination therapy. All SSRIs except paroxetine (Paxil) have pharmacologically active metabolites.The most common interactions with SSRIs result from an inhibitory effect of the SSRI on the cytochrome P450 2D6 pathway, although variability in this inhibition exists. Because of new clinical recommendations, the use of warfarin (Coumadin) has increased in recent years. Cisapride has been associated with prolongation of the QT interval, torsades de pointes, syncope, cardiac arrest and sudden death.The primary agents contraindicated for use with cisapride are certain macrolide antibiotics (erythromycin and clarithromycin), certain antifungal agents (fluconazole, itraconazole [Sporanox] and ketoconazole [Nizoral]), one antidepressant drug (nefazodone [Serzone]) and certain protease inhibitors (indinavir [Crixivan] and ritonavir [Norvir]).Most data on cisapride interactions are derived from case reports. Minor drug interactions do not usually cause harm or require a change in therapy. Take this medication at least 2 hours before or 6 hours after taking sucralfate and products containing aluminum or It is very important to continue taking this medication exactly as prescribed by your doctor.