Ondansetron should be administered immediately before chemotherapy as a single intravenous dose of 0.15 mg/kg. Anti-diarrhoeals are not recommended. This website also contains material copyrighted by 3rd parties. Splinter, W. M., et al, Prophylactic antiemetics in children undergoing tonsillectomy: high-dose vs low-dose ondansetron, Paediatr Anaesth, 1997, 7(2), 125-9 Tan, J., et al. Hepatic Dose : Per the manufacturer, ondansetron dosage should not exceed 8 mg/day IV or PO ... plasma clearance is reduced, resulting in a dramatically prolonged elimination half-life. Dose: 8 mg PO q8h x2 doses, then 8 mg PO q12h until 1-2 days after chemo complete; Start: 30min before chemo; Info: do not cut/chew ODT form nausea/vomiting prevention, postop [1 mo-12 yo and 40 kg] Dose: 0.1 mg/kg/dose IV x1; Max: 4 mg/dose; Info: give immed. -Recommended dose: 0.15 mg/kg IV, with the first dose (infused over 15 minutes) 30 minutes before the start of emetogenic chemotherapy and subsequent doses given 4 and 8 hours after the first dose.-Maximum dose: 16 mg per dose Comments:-Multi-day, single-dose administration of 24 mg orally for HEC has not been studied. Portions of this document last updated: Sept. 01, 2020Copyright © 2020 IBM Watson Health. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.If you miss a dose of this medicine, take it as soon as possible. Then, the dose is 4 mg every 8 hours for 1 to 2 days. 1 month-12 years. Under 40 kg, 0.1 mg/kg intravenously . , Palonosetron is nonsuperior to ondansetron in acute phase but provides superior antiemetic control in delayed phase for pediatric patients administered highly emetogenic chemotherapy., Pediatr Blood Cancer, 2018, 65 (2) The 4-mg dose is taken again 4 and 8 hours after the first dose. 2010 Diseases & Conditions Diseases & Conditions Peds Dosing . ≥6 months: 0.15 mg/kg over 15 min administered 30 min before chemotherapy, then repeated 4 and 8 hr after first dose; not to exceed 16 mg/dose (32 mg no longer recommended because of increased risk of QT prolongation) Postoperative Nausea & Vomiting. 1 month-12 years. Table 1: Ondansetron wafer dose (drug dose) Weight Ondansetron wafer dose 8 -15 kg 2mg. Follow your doctor's orders or the directions on the label. 1355706-overview Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Drugs If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. The dose of this medicine will be different for different patients. All rights reserved. 15-30 kg ... Ondansetron wafer dose 8 -15 kg Store at room temperature, away from heat and direct light. encoded search term (ondansetron (Zofran%2C Zuplenz)) and ondansetron (Zofran, Zuplenz) The New Gastroenterology Data That Primary Care Teams Need to Know Hematology-Oncology Guidelines: 2017 Midyear ReviewTime to Stop Pressuring Women on Screening Mammography?Mammography Starting at 40 Cuts Risk of Breast Cancer Death Share cases and questions with Physicians on Medscape consult. Although … Contact the applicable plan Available for Android and iOS devices. Select one or more newsletters to continue. All rights reserved. If you log out, you will be required to enter your username and password the next time you visit. Controlled studies in pregnant women show no evidence of fetal risk.Mechanism not fully characterized; selective 5-HT3 receptor antagonist; binds to 5-HT3 receptors both in periphery and in CNS, with primary effects in GI tractHas no effect on dopamine receptors and therefore does not cause extrapyramidal symptomsBioavailability: 56-71% (PO); food increases extent of absorption (17%)Peak plasma time: IV, end of infusion; IM, 30 min; PO, 2 hr (tablet) or 1 hr (soluble film)Extensive hepatic metabolism, with hydroxylation followed by glucuronide (indole ring) or sulfate conjugation; metabolized by CYP2D6 and partly by CYP1A2 and CYP3A4Metabolites: Glucuronide conjugate, sulfate conjugate (inactive)Half-life: 2-7 hr (children <15 years); 3-7 hr (adults); patients with mild to moderate hepatic impairment, 12 hr; patients with severe hepatic impairment (Child-Pugh class C), 20 hrY-site: Acyclovir, allopurinol, aminophylline, amphotericin B, amphotericin B cholesteryl sulfate, ampicillin, ampicillin/sulbactam, amsacrine, cefepime, cefoperazone, 5-fluorouracil (5-FU; at 1 mg/mL ondansetron and 16 mg/mL 5-FU; may be compatible at 0.8 mg/mL 5-FU and up to 160 mcg/mL ondansetron), furosemide, ganciclovir, lorazepam, meropenem (at 50 mg/mL meropenem and 1 mg/mL ondansetron; may be compatible at 1 mg/mL each), methylprednisolone, piperacillin, sargramostim, sodium bicarbonateAdditive (partial list): Cisplatin, cyclophosphamide, cytarabine, decarbazine, dacarbazine with doxorubicin(?