For this reason, you should inform your doctor if you experience an upset stomach pain or any yellowing of the skin or the whites of the eyes (jaundice) while taking this medication.Tell your doctor or pharmacist if you have had an allergy before.If you feel you have experienced an allergic reaction, stop using this medicine and tell your doctor or pharmacist immediately.Certain medications should not be used during pregnancy or breastfeeding.However, other medications can be used safely during pregnancy or breastfeeding, as long as the benefits to the mother outweigh the risks to the fetus.Always inform your doctor if you are pregnant or planning a pregnancy, before using any medication.Talk to your doctor right away if you think you might be pregnant while taking this medication, or if you want to try a baby.It is not known if this medication passes into breast milk. 1991;40(1):33-41. doi: 10.1007/BF00315136.Drugs. Bezafibrate is rapidly eliminated, and thus does not accumulate during prolonged administration in patients with normal renal function. During long term therapy (2 to 4 years) the influence of bezafibrate on the lipid profile is sustained. These effects are equivalent in patients with primary hyperlipoproteinaemia or hyperlipoproteinaemia secondary to diabetes or renal disease, although dosage adjustment is important in the latter group. Please enable it to take advantage of the complete set of features! Evidence from studies in rodents and in humans is available to implicate 5 major mechanisms underlying the above-mentioned modulation of lipoprotein phenotypes by fibrates: 1. Author information: (1)State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. However, because it could cause side effects in an infant, the manufacturers of Bezafibrate indicate that it should not be taken by women who are breastfeeding.Women who need to take this medication should not breastfeed their babies and use formula instead. Springer In turn, it also decreases the production of triglycerides by the liver. Simvastatin and Bezafibrate ameliorate Emotional disorder Induced by High fat diet in C57BL/6 mice. Experimental studies have shown bezafibrate to have a complex range of effects on lipoproteins and on the enzymes and receptors involved in lipid metabolism. It is used to lower high levels of fats (lipids) such as triglycerides and blood cholesterol ( For the sake of simplicity, there are two types of cholesterol; a “bad” type called low-density lipoprotein (LDL) and a “good” type called high-density lipoprotein (HDL).LDL is deposited in the arteries and increases the risk of heart disease by clogging and narrowing the arteries (atherosclerosis), while HDL actually protects the arteries against this.Triglycerides are another type of “bad fats” that increase the risk of hardened arteries.Stimulating these enzymes increases the breakdown of triglycerides in the blood.In turn, it also decreases the production of triglycerides by the liver. Mechanisms of Action of Fibrates. Google Adsense uses “cookies” (text files) that are stored on your computer and allows an analysis of the use of this website by you. This site needs JavaScript to work properly. Elevated VLDL and LDL are reduced by treatment with bezafibrate, whilst HDL-levels are increased. Springer 2020 Jan 31;15:705-715. doi: 10.2147/IJN.S235146. 2015 Aug;62(2):635-43. doi: 10.1002/hep.27744. Experimental studies have shown bezafibrate to have a complex range of effects on lipoproteins and on the enzymes and receptors involved in lipid metabolism. At its recommended dosage of 200 mg 3 times daily, or alternatively 400 mg once daily as a sustained-release preparation, it produces substantial reductions in plasma triglyceride and cholesterol concentrations in patients with hypertriglyceridaemia and hypercholesterolaemia, respectively. 2003 Nov;64(9):697-706. doi: 10.1016/j.curtheres.2003.10.002. Bezafibrate is rapidly eliminated, and thus does not accumulate during prolonged administration in patients with normal renal function. Clipboard, Search History, and several other advanced features are temporarily unavailable. Given, however, the similar mechanisms of action and effects on lipids, no considerable differences in terms of efficacy and safety were expected. 1983;25(1):57-63. doi: 10.1007/BF00544015.Sun R, Shen C, Shafique S, Mustapha O, Hussain T, Khan IU, Mehmood Y, Anwer K, Shahzad Y, Yousaf AM.Int J Nanomedicine. 1999 Jul;16(7):1093-7. doi: 10.1023/a:1018900219616.Eur J Clin Pharmacol.