You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more.Hydroxychloroquine (200mg/tab) 1 tab twice daily orally for 6 monthsCheck anti-TPO antibody 6 months after medical treatment as inflammatory markerCheck serum anti-thyroglobulin antibody 6 months after medical treatment as inflammatory statusMeasure the elasticity of the thyroid gland by elastography as the infiltrative degree of the thyroidMeasure serum free T4 and thyroid-stimulating hormone level 6 months after treatmentMeasure plasma cytokines including interleukin-1, interleukin-6, tumor necrosis factor-alpha, 6 months after treatment Hang in there. how long does it take for plaquenil to get out of your system Question quickly subdues him by asking him philosophical riddles in return. You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more.Start Plaquenil 200mg BID orally since enrollment Duration: 6 monthsStart Plaquenil 200mg BID orally since the 25th week after enrollment Duration: 6 monthsChange of serum thyroid autoantibodies including anti-TPO antibody and anti-thyroglobulin antibody at baseline, and every 3 months after treatment intervention up to 18 monthsChange of serum inflammatory markers, including hsCRP and ESR at baseline, and every 3 months after treatment intervention up to 18 monthsChange of serum proinflammatory markers and cytokine level at baseline, and every 3 months after treatment intervention up to 18 monthsChange of thyroid volume measured by ultrasound at baseline, and every 3 months after treatment intervention up to 18 monthsKeywords provided by National Taiwan University Hospital:
Hashimoto's thyroiditis is an autoimmune thyroid disease, which induced chronic inflammation of thyroid gland and destroys thyroid tissue.Hydroxychloroquine is used as disease modifying anti-rheumatic drug (DMARD) for treatment of several autoimmune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis(RA) for more than one century.The purpose of this study is to evaluate whether hydroxychloroquine is effective in treatment of Hashimoto's thyroiditis.Hashimoto's thyroiditis is an autoimmune thyroid disease, and when the disease progresses, thyroid function finally declined to hypothyroidism.There was no medical treatment recommended for patients with Hashimoto's thyroiditis, but currently at euthyroid state. The plaquenil gives me such relief that I would continue to take it even if it did interfere with the thyroid meds. Various auto-antibodies may be present against TPO and Tg, and ADCC is a substantial factor behind the apoptotic fall-out of HT. The major auto-antigens include thyroid peroxidase (TPO) and thyroglobulin. It reduced lymphocytes, production of auto-antibodies, … Some are beneficial for hyperthyroidism but can worsen the symptoms of hypothyroidism, and vice versa.
However, there is no suggested treatment for subjects with HT who have normal thyroid function. These include interaction with sulphydryl groups, interference with enzyme activity (including phospholipase, nicotinamide adenine dinucleotide hydrogen-cytochrome C reductase, cholinesterase, proteases and hydrolases), DNA binding, stabilisation of lysosome membranes, inhibition of prostaglandin formation, inhibition of polymorphonuclear cell chemotaxis and phagocytosis.This study is to investigate the treatment effect of hydroxychloroquine on autoantibodies and disease progression of Hashimoto's thyroiditis. There was no medical treatment recommended for patients with Hashimoto's thyroiditis, but currently at euthyroid state. Neonates from mothers with ATD have higher rate of transient hypothyroidism. The thyroid gland attacked by a variety of cell- and antibody-mediated immune processes. The annual incidence of HT worldwide is estimated to be 0.8 - 3.5 cases per 1000 persons.